The Peptide Evidence Guide

 

​A searchable reference to the compounds people ask about most — rated honestly by what the research actually shows, not by what sells.

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Almost everything written about peptides online is trying to sell you something. The result is a landscape where a compound with fifty years of human research and a compound tested only in mice get described in the same confident language. The peptide evidence guide exists to undo that. It's a searchable reference to the peptides and related compounds that clients ask about most, and it does the one thing the sales pages won't: it tells you, plainly, how much human evidence actually stands behind each one.

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Every compound in the peptide evidence guide is graded on a five-tier evidence ladder and paired with a clear-eyed summary of what it is, how it works, and — most importantly — where the science is strong and where it runs well ahead of the data. You'll find what each compound has been studied for. You will not find doses, sources, or protocols, and that is deliberate. More on why below.

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How the Peptide Evidence Guide Rates Each Compound

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The evidence tiers run from Tier 1 to Tier 5. Tier 1 is reserved for compounds with genuine regulatory approval and multiple large human trials — the incretin therapies such as semaglutide and tirzepatide, and the specific approval held by tesamorelin. Tiers 2 and 3 cover compounds with real but narrower human data. Tier 4 marks the ones resting largely on preclinical and animal research with limited human validation — a category that quietly includes several of the most heavily marketed peptides on the market. Tier 5 is preclinical only: interesting in a lab, unproven in people.

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The honest caveats aren't a disclaimer bolted onto the end — they're the entire point. When a compound failed its human trials, the guide says so. When the strongest research comes from a single country and hasn't been independently confirmed in the West, the guide says that too. The goal isn't to talk you into anything or out of anything. It's to let you see the difference between an established therapy and a hopeful one before anyone asks you to act on it.

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Where Peptides Fit in Body Recomposition After 40

 

Peptides are one pillar of the PowerSkulpt Method — Targeted Biology and Hormone Support — not the foundation, and not a shortcut. After 40, no compound compensates for a recovery system under chronic strain or a metabolism downregulated by years of undereating and overtraining. That is why PowerSkulpt is recovery-first: the biology only responds once the foundation beneath it is stable. It's the same principle behind the six pillars of the PowerSkulpt Method, and the reason our most-read retatrutide guidance spends more time on sleep, stress, and training load than on the molecule itself. The compound is the easy part. Sequencing it correctly, for your body, is the work.

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What the Peptide Evidence Guide Won't Give You

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You will not find dosing, titration schedules, injection protocols, sourcing, or pricing anywhere in this guide — not because they're secret, but because they're clinical decisions, not published content. Which compound, in what order, at what dose, alongside which bloodwork, is the part that requires a clinician and a coach who knows your history. Publishing that as a lookup table would be the opposite of responsible, and the opposite of how PowerSkulpt works. The guide gives you the map. The route is personal, and it stays private. If a compound here turns out to be relevant to you, the honest next step is a conversation — and, where hormones are involved, real bloodwork, because symptoms and marketing are a pattern, not a plan.

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“Training creates the signal. Recovery creates the change.”

 

Most programs start with training. PowerSkulpt starts with recovery.

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Start with the Method, not the molecule.

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The Protocol Briefing is a free overview of how the PowerSkulpt Method rebuilds each layer of your foundation in the right order — including where targeted biology fits. When you're ready to talk to us, book a free 20-minute Assessment Call — no cost, no pressure. If retatrutide is your focus, start with the Retatrutide Troubleshooter.

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Explore the guide below.

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PowerSkulpt is a recovery-first body recomposition coaching practice for high-performing adults over 40. This guide is educational and does not diagnose, treat, or prescribe. Compounds discussed may not be approved by Health Canada or the FDA for the uses referenced. Always consult a qualified physician before making changes to training, nutrition, or any protocol.

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